http://www.newsweek.com/fatty-liver-disease-wrinkles-dna-gene-expression-948291

Wrinkles aren’t just a sign of aging on our outward appearance, but also can occur deep inside on a cellular level. Wrinkles on our cells’ nuclei can interfere with certain genes and contribute to illnesses such as fatty liver disease. Smoothing out these wrinkles may be the answer.

In a study published online in Aging Cell, researchers from the University of Virginia School of Medicine noted that as cells age, their nuclei, or the cell center, can also develop wrinkles similar to those that appear in aging skin. The nucleus takes up about 10 percent of the cell’s volume, and also contains our DNA. As a result, this wrinkling can affect gene expression and lead to more serious health problems, including type 2 diabetes and cardiovascular disease, which can result in death, MedicalXpress reported.