Researchers led by Guo Jingtao and Wang Xiaoyan mapped human urogenital development in embryos at three Carnegie stages using spatial transcriptomics and single-cell multi-omics. The study reports that neighboring tissues signal the early gonad and that adrenal and gonadal steroidogenic programs are coordinated during sex differentiation.
Alphabet, Amazon, Meta and Microsoft plan over $740 billion in AI-related capital spending this year, but investors are questioning free cash flow, debt and returns as share prices fall. Alphabet and Amazon reported negative free cash flow, while Microsoft stayed positive.
Anthropic is expected to get a high speculative-grade credit rating after going public, per a Financial Times report. Blackstone, anchor investor in a $63 billion chip-financing deal, reportedly now forecasts a double-B rating, reversing its earlier investment-grade expectation.
Intel shares fell about 28% Friday after the chipmaker projected fourth-quarter revenue of $15 billion to $16 billion and a lower gross margin, cutting the government's stake value by $12 billion. Intel said memory prices and availability are pressuring PC demand, while data-center revenue rose 78%.
Canada and the European Union are pursuing the EU's first associate membership, a deeper partnership Prime Minister Mark Carney announced at a Montreal press conference. Carney expects the arrangement, involving more than 20 new measures, to be finalized by June 2027.
A new Uppsala University thesis examining Swedish compulsory-school grades from 1998 to 2022 finds that pupils at for-profit independent schools earn higher grades than their backgrounds would predict. This suggests more lenient grading that may advantage high-income pupils in competing for upper secondary places.
Binance, the world's largest crypto exchange, reported a suspected hack with estimated impact near $6.3 billion, about $3 billion of it frozen on-chain, and suspended deposits and withdrawals. Its initial probe points to a compromised DevOps engineer's laptop, and Tether and Circle froze funds.
DoorDash said on its Q3 earnings call that third-party AI agents have placed only "several hundred" orders, versus about 3 million daily deliveries. CEO Tony Xu noted most users still order through the app, though the company is building its own agents and may eventually advertise within third-party ones.
An AP analysis finds more than 43 million Americans had voted early five days before Election Day, nearly 10 million more than in 2022, with sharp jumps in Senate battleground states such as Texas, where early voting is up 50%.
Theranos whistleblower Tyler Shultz says the Holmes documentary keeps attention on her by design, and warns that AI-era investing resembles Theranos funding: hard-to-verify technology, little due diligence, and huge valuations that invite deception.
As the 2026 midterms approach, both parties face a reckoning: some Republicans are distancing themselves from Trump while Democrats are split between establishment leaders and emboldened progressives. The results will launch fights over each party's direction and the 2028 race.
Tarkash Labs presents OmniGuard AI, an open-source Manifest V3 Chrome extension that screenshots the viewport, sends it to a stateless FastAPI backend where Gemini Flash flags six kinds of dark patterns, and overlays bounding boxes via Shadow DOM. Screenshots are held only in memory and then discarded.
A remotely exploitable use-after-free bug affects Linux systems with multipath TCP listeners, caused by a race between handling a retransmitted SYN and connection establishment. The fix delays freeing the structure until an RCU grace period; Go programs use multipath TCP by default, so users should apply patched kernels.
LocalStack has released its Azure emulator in free public preview, with general availability targeted for early 2027. Its documentation discloses that many settings are stored without being enforced, and that several services implement only a fraction of their API operations.
An essay argues that horror cinema inverts the road's promise of freedom, treating highways as routes to dread and the un-understandable. Drawing on Psycho, Lost Highway and The Hitcher, it reads driving as a split, dreamlike state from which no one truly escapes.
An essay on Blade Runner's lasting power, drawing on Stephen Vaughan's set photographs of Harrison Ford, Sean Young and Daryl Hannah. It ties the film's city detail, loneliness and shifting cuts to Philip K. Dick's novel and to nostalgia for a future now in the past.
An essay on Blade Runner's lasting power, drawing on Stephen Vaughan's set photographs of Harrison Ford, Sean Young and Daryl Hannah. It ties the film's city detail, loneliness and shifting cuts to Philip K. Dick's novel and to nostalgia for a future now in the past.
A federal judge ruled that the EPA may intervene in the Clean Air Act suit over xAI's Memphis-area gas turbines but cannot unilaterally end it once it joins. The suit was brought by SELC, Earthjustice and the NAACP, and the Trump administration had sought dismissal.
Saikat Chakrabarti filed an FEC complaint alleging that Sen. Scott Wiener’s congressional campaign may have illegally coordinated and shared expenses with a PAC, Families for an Affordable San Francisco. Wiener’s campaign dismissed the complaint as a political ploy tied to Chakrabarti’s support for Connie Chan.
The European Space Agency's Hera spacecraft has returned its first image resolving the Didymos and Dimorphos asteroid pair as separate objects. It will follow up NASA's DART impact by deploying two CubeSats to examine Dimorphos' surface and interior.
A developer reports that the VS Code Swift extension invokes the swiftly tool every two seconds in a loop, and that swiftly issues an unconditional network request on each call, even though the resulting update notice is never shown to users. Suggested fixes include a disable-update-check flag, a tty check, or caching the result for at least 30 minutes.
Adobe Books, a volunteer-run co-op on San Francisco’s 24th Street, was splattered with paint for the third time in six days, leaving its storefront windows obscured. Volunteers say they do not know why the store was targeted but suspect a political motive, and the co-op is filing a police report.
Google says its PageBreak security agent has found over 500 XSS vulnerabilities in its web applications since January. The Gemini-based system reports flaws only after deterministic validators reproduce an exploit, yielding a near-zero false-positive rate; Google has provided no independent validation.
San Francisco's transit agency confirmed that ICE has assigned parking in the city-owned Golden Gateway Garage, and activists allege agents have staged enforcement there. Officials are investigating whether the arrangement violates sanctuary laws; a supervisor who wrote related legislation says he was unaware.
The article says Asian defense ministries renting Starlink should examine contract terms, citing Ukraine’s experience and reported jamming near Scarborough Shoal. It urges joint safeguards like advance notice of service changes, emergency price locks and terminals able to switch constellations.
