https://www.sciencedaily.com/releases/2022/02/220217141309.htm

Until now, researchers could capture the motion of a single molecule, and they could capture its rotation -- how it tumbles as it bumps into surrounding molecules -- but only by compromising 3D resolution.

Now, the lab of Matthew Lew, assistant professor of electrical and systems engineering at the McKelvey School of Engineering at Washington University in St. Louis, has developed an imaging method that provides an unprecedented look at a molecule as it spins and rolls through liquid, providing the most comprehensive picture yet of molecular dynamics collected using optical microscopes.