https://motherboard.vice.com/en_us/article/8xeenb/lsd-dmt-neuroplasticity-depression-ptsd > This story is part of When the Drugs Hit, a Motherboard journey into the science, politics, and culture of today's psychedelic renaissance. Follow along here . > LSD and DMT have long been substances of choice in the psychonaut community, and with good reason. Both of these substances are known to profoundly alter a user’s mental state and and result in vivid hallucinations. Yet due to a decades-long moratorium on psychedelic research in the United States, researchers still don’t have a very good picture of how these mind-altering drugs are actually affecting the brain at a physical level.