https://phys.org/news/2018-05-genome-pairs.html

In the present study, the researchers used human cell lines with different ploidy states—haploid, diploid and tetraploid—to investigate the effect of the differences on the cell replication process.

In normal cells, there are two centrosomes, which are regulators of cell replication. The researchers observed gradual loss of centrosomes in haploid cells and frequent over-duplication of centrosomes in tetraploid cells, both of which triggered frequent abnormalities in the cell replication process.