Gene therapy trials for sickle cell disease halted after two patients develop cancer

Gene therapy trials for sickle cell disease halted after two patients develop cancer

3 years ago
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http://www.sciencemag.org/news/2021/02/gene-therapy-trials-sickle-cell-disease-halted-after-two-patients-develop-cancer

There are new cancer concerns swirling around a gene therapy approach designed to prevent the sickling of blood cells (above).

A company has stopped its clinical studies of a promising gene therapy for the blood disorder sickle cell disease after two people who participated developed leukemia-like cancer. Bluebird bio is now investigating whether a virus it uses to deliver a therapeutic gene caused the cancers, reviving old concerns about the risks of this approach.

Gene therapy trials for sickle cell disease halted after two patients develop cancer

Feb 17, 2021, 12:43am UTC
http://www.sciencemag.org/news/2021/02/gene-therapy-trials-sickle-cell-disease-halted-after-two-patients-develop-cancer > There are new cancer concerns swirling around a gene therapy approach designed to prevent the sickling of blood cells (above). > A company has stopped its clinical studies of a promising gene therapy for the blood disorder sickle cell disease after two people who participated developed leukemia-like cancer. Bluebird bio is now investigating whether a virus it uses to deliver a therapeutic gene caused the cancers, reviving old concerns about the risks of this approach.