Learning from three centuries of smallpox epidemics in London, UK
https://www.sciencedaily.com/releases/2020/12/201221140501.htm
Smallpox, one of the most devastating viral diseases ever to strike humankind, is one of only two infectious diseases that have been successfully eradicated by human efforts. 2020 marks the 40th anniversary of smallpox eradication.
Krylova and Earn studied more than 13,000 weekly smallpox mortality records, from 1664 to 1930, and found that the time between epidemics, the size of the outbreaks, and even the season when the epidemics occurred, changed over the centuries. They also annotated the smallpox time series with major historical events, including the introduction of various control interventions, before and after the discovery of a vaccine in 1796.