http://www.prnewswire.com/news-releases/elysium-health-announces-clinical-trial-to-explore-the-effect-of-basis-on-liver-fat-accumulation-in-healthy-adults-with-fatty-liver-nafl-300962995.html

NEW YORK, Nov. 21, 2019 /PRNewswire/ -- Elysium Health, Inc.,™ a life sciences company developing clinically validated health products based on advancements in scientific research, today announced the completion of enrollment for a clinical trial to explore the effect of Basis™ on liver fat accumulation in healthy adults with nonalcoholic fatty liver (NAFL). NAFL is a precondition that affects approximately 80–100 million Americans that currently has no treatment—as the name suggests, the main characteristic is an accumulation of fat stored in the liver. While NAFL is not a disease, the current obesity epidemic is paralleled by manifestations of metabolic syndrome, such as insulin resistance, elevated blood pressure, increased waist circumference, and hypertriglyceridemia. All of these biomarkers are also conditions that are associated with excessive accumulation of liver fat, indicating that fatty liver may be regarded as the hepatic manifestation of metabolic syndrome.

Basis is a combination of Elysium Health's proprietary nicotinamide riboside (NR) and pterostilbene (PT), which is designed to increase NAD+ levels and activate sirtuins. As an essential coenzyme involved in hundreds of metabolic processes, NAD+ has a critical role in the conversion of NAD+ to NADH for mitochondrial metabolism and the resulting synthesis of ATP, which is how cells create energy. The activation of sirtuins – which are NAD-dependent – also regulates important physiological processes like lipid metabolism. In an earlier clinical trial, Basis was shown to increase and sustain NAD+ levels on average by 40% from baseline.