http://www.sciencemag.org/news/2020/02/another-hiv-vaccine-strategy-fails-large-scale-study

Copies of HIV (yellow) infecting a white blood cell

The failure-ridden search for a vaccine that can stop the AIDS virus has delivered yet another frustrating defeat. The HIV vaccine that had moved furthest along in human testing does not work, and the $104 million trial in South Africa evaluating it has been stopped early. “There’s absolutely no evidence of efficacy,” says Glenda Gray, who heads the study and is president of the South African Medical Research Council (MRC) in Cape Town. “Years of work went into this. It’s a huge disappointment.”