https://phys.org/news/2018-10-virus-production-boosted-cells-vectors.html

Viruses contain only a limited amount of genetic material, so they need to enter cells and hijack some of their hosts' machinery in order to survive and reproduce. In this latest work reported in the journal Scientific Reports, the team focused on some of the molecules that, when present in the host, can help viruses to do this, in this case for the HIV-1 virus.

                                
                
            
                    
    
    Co-transfection with Tax expression plasmid augments transgene expression. Credit: Department of Molecular Virology,TMDU

"We first focused on the effects of the SPSB proteins, by expressing them in human embryonic kidney cells along with a plasmid for HIV-1," Shoji Yamaoka says. "SPSB1, but not SPSB2 and 3, boosted the release of HIV-1 from these cells, which was revealed by increased viral infection of indicator cells that exhibited bioluminescence upon infection."