https://phys.org/news/2018-10-rna-protein-network-melanoma.html

"We identified a long non-coding RNA named SAMMSON expressed in the vast majority (>90 percent) of melanoma patients and never detected in normal adult tissues," said co-senior author Dr. Eleonora Leucci, LKI Leuven Cancer Institute, KU Leuven. "In melanoma, SAMMSON is essential for proper localization of the protein p32 into the mitochondria, where it is essential for ribosome biogenesis and protein synthesis."

"We reported that protein CARF presents in the nucleoplasm, indirectly reduces the ribosome synthesis in the nucleolus through directly binding to another protein XRN2," said co-author Dr. Hideaki Ishikawa, Department of Agriculture, TUAT, Tokyo, Japan. "In the nucleolus, XRN2 acts as an enzyme that increases the ribosome synthesis. But its activity and localization are regulated by CARF whose binding keeps XRN2 away from the nucleolus."