https://phys.org/news/2018-08-crispr-safety-genome-vandalism.html

But a few recent scientific papers suggest that CRISPR is not without its problems. The research reveals that CRISPR can damage DNA that is far from the target DNA we are trying to correct. As a cancer biologist at the University of Pittsburgh School of Medicine, I use CRISPR in my lab to study human cancers and develop ways to kill cancer cells. Although the new finding appears significant, I don't think that these revelations rule out using the technology in a clinical setting, but rather, they suggest we take additional cautionary measures as we implement these strategies.

Using genome editing to treat human diseases is very tantalizing. Correcting inherited genetic defects that cause human disease –just as one edits a sentence – is the obvious application. This strategy has been successful in tests on animals.