![From metabolism to function—the extreme structural adaptations of photoreceptors](https://i.comentr.com/_DmlF4WlzefoN-7lLk5Blm9zrqs_tam.jpg)
From metabolism to function—the extreme structural adaptations of photoreceptors
https://phys.org/news/2018-06-metabolism-functionthe-extreme-photoreceptors.html
The concentration of hexokinase II in cancer cells is typically increased up to 200-fold. These cells can therefore maintain a high glycolytic rate even in the presence of abundant oxygen. This extreme 'aerobic glycolysis' in tumors is frequently called the Warburg effect. Curiously, photoreceptors also show this high hexokinase II expression and aerobic glycolysis, but cancers of the retina are very rare. When tumors do form they usually occur in either the pigment epithelial cells, or early in development in cones that have a double knockout to both copies of their retinoblastoma gene.
The retinoblastoma gene (RB) is known as a tumor suppressor gene. It is critical in controlling the precise number of cells within several sensory systems that build elaborate ciliary structures as detectors. In the cochlea, for example, there is an overpopulation of hair cells and loss of hearing when RB is absent. In adults with hearing loss, it might be possible to regenerate new hair cells by artificially reducing RB activity. Some researchers have even suggested that RB control pathway is the big one that first made multicellular life possible.