What are potentially unwanted applications?
https://www.bleepingcomputer.com/news/microsoft/windows-10-to-automatically-block-potentially-unwanted-apps/
Microsoft Defender and Microsoft Edge on Windows 10 will automatically block potentially unwanted applications (PUAs) by default starting this month.
Starting with the Windows 10 2004, the May 2020 update, Microsoft added a new 'Potentially unwanted app blocking' setting in Windows security that causes Microsoft Defender to block these types of applications.