http://www.pcgamer.com/skyrim-script-extender-64-for-skyrim-special-edition-is-in-alpha/

Modders and mod users alike have been eagerly awaiting the arrival of a version of Skyrim Script Extender that is compatible with Skyrim Special Edition. That day still hasn't arrived, though after some delays and news that SKSE64 wasn't even being worked on, there's still some good news here. An alpha has appeared, and while it's only intended for mod authors to check out and begin testing, it's still a good sign that someday a full version might be available for everyone.

The Script Extender is a mod other Skyrim mods rely on, as it expands Skyrim's scripting capabilities and allows for added complexity and functionality. A number of mods for the original Skyrim have not been ported over to the Special Edition yet, simply because the same level of functionality isn't available without the SKSE.