https://wccftech.com/red-dead-redemption-2-game-breaking-bug/

It appears that various players are suffering from a Red Dead Redemption 2 game breaking bug that results in the loss of 4 characters throughout the game.

As posted on the Red Dead Redemption Reddit, starting the Uncle Mission in chapter 2 as your first mission without talking to John, Abigail, Jack and Sadie first, will result in the loss of those characters. It was first thought that those characters would be lost for the rest of the game, but various users have stated that these characters are restored at chapter 4. We’ve included a part from the Reddit post below, including a way to prevent the bug from happening.