https://www.gamespot.com/articles/fallout-76-wont-let-you-respec-your-specials/1100-6462416/

Fallout 76 is a new kind of game for the franchise, presenting a connected persistent world. You'll be persistent too, as Bethesda marketing VP Pete Hines has confirmed that once you assign your SPECIAL points, you can't respect them.

A fan on Twitter asked what can be done if he reaches level 50, has spent all of his SPECIAL points, and feels unhappy with his character build. Can he respec or does he need to start a whole new character from scratch? Hines answered plainly.