https://www.gamespot.com/articles/red-dead-redemption-2s-random-npc-encounters-can-t/1100-6462208/

From all that we've seen of Red Dead Redemption 2 thus far, it's evident Rockstar Games has crafted a detailed and reactive world to explore in its much anticipated western sequel. Not only will the non-playable characters you encounter snitch on your crimes if they see you engaging in some shady activities, you'll be able to interact with strangers you come across in various other ways, which can have some unexpected consequences.

During our most recent hands-on session with Red Dead Redemption 2, we were traveling leisurely down a dirt path that led to a crossroads. There, we encountered an older gentleman on the side of the road affixing a horseshoe to his horse. As we passed him, the game presented several different interaction prompts, giving us the option to Callout or Antagonize him. We chose to greet him, and in return, he stopped what he was doing and greeted us back.