https://wccftech.com/todd-howard-fallout-76-questions/

Todd Howard, Head of Bethesda Game Studios, revealed new details about Fallout 76, the franchise’s first multiplayer entry, during an interview today with Geoff Keighley’s YouTube Live @ E3. Specifically, he addressed popular concerns in the community regarding the confirmed lack of human NPCs, the potential PvP issues, how the VATS and modding systems will work in the online-only environment.

There is a questline. There are no human NPCs but there’ll be robots, terminals, holotapes and therefore questlines.