https://phys.org/news/2018-05-ornl-ramps-production-key-radioisotope.html

Ra-223, the active ingredient in Xofigo, is currently derived from global supplies of existing Ac-227. After the U.S. Food and Drug Administration approved Xofigo in 2013, it was clear an alternative source of Ac-227 was needed. The drug is now approved in 52 countries worldwide.

"As part of our longstanding commitment to improving the lives of those living with cancer, we are honored to be working with the Department of Energy and Oak Ridge National Laboratory's radioisotope production experts and their unique facilities to ensure a sustainable supply of this important drug, Xofigo, into the foreseeable future," said Carsten Brunn, president of Bayer Pharmaceuticals, Americas Region.