https://wccftech.com/capcoms-art-director-talks-inspirations-for-lady-dimitrescu-says-hers-is-only-a-section-of-resident-evil-village/

The Internet's peculiar fondness for Resident Evil Village villain Lady Dimitrescu continues unabated, so we expect many will be interested in the origins of the character. CAPCOM Art Director Tomonori Takano cited three main inspirations in an interview with IGN: real-life noblewoman and serial killer Elizabeth Báthory, Japanese Internet legend Hasshakusama, and Morticia Addams.

In the early stages of planning, we decided on going with castle and vampires motifs. However, we did not want to be constrained by how vampires have been portrayed in various forms of popular entertainment.